Immunization of institutionalized asthmatic children and patients with psychomotor retardation using live attenuated cold-adapted reassortment influenza A H1N1, H3N2 and B vaccines
Identifieur interne : 001E77 ( Main/Exploration ); précédent : 001E76; suivant : 001E78Immunization of institutionalized asthmatic children and patients with psychomotor retardation using live attenuated cold-adapted reassortment influenza A H1N1, H3N2 and B vaccines
Auteurs : Chiaki Miyazaki [Japon] ; Minako Nakayama [Japon] ; Yoshifumi Tanaka [Japon] ; Koichi Kusuhara [Japon] ; Kenji Okada [Japon] ; Ken Tokugawa [Japon] ; Kohji Ueda [Japon] ; Rumiko Shibata [Japon] ; Sankei Nishima [Japon] ; Nobuhisa Yamane [Japon] ; H. F. Maassab [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 1993.
English descriptors
- Teeft :
- Adenovirus type, Adverse reactions, Antibody responses, Antibody titres, Asthma, Asthmatic, Asthmatic children, Attenuated, Attenuated influenza vaccine, Bivalent, Body temperature, Bronchial asthma, Exact test, Febrile, Immunization, Influenza, Influenza virus vaccines, Inoculated, Inoculation, Monovalent, Monovalent vaccine, Nosocomial, Nosocomial outbreak, Outbreak, Reassortant, Research institute, Seronegative, Seronegative children, Seropositive, Severe psychomotor retardation, Split vaccine, Titre, Trivalent, Trivalent vaccine, Vaccination, Vaccine, Vaccine preparations, Vaccine strain, Vaccine strains, Vaccinee, Virus isolation, Young children.
Abstract
Abstract: Live attenuated cold-adapted reassortant (CR) influenza virus vaccines were evaluated in institutionalized asthmatic children and severe psychomotor-retarded (SPR) patients. Almost all the vaccines were seropositive to the vaccine strains before immunization. Trivalent CR vaccine (containing A H1N1 (CR-125), A H3N2 (CR-149) and B (CRB-117)), bivalent CR vaccine (CR-125 and CR-149) and monovalent CRB-117 were inoculated to 19 asthmatic children and 36 and 16 SPR patients, respectively. Overall 49, 22, 11% of vaccinees were infected by A H1N1, A H3N2 or B vaccine viruses, respectively, as indicated by significant haemagglutination-inhibition (HI) antibody titre rises 4 weeks after inoculation. No severe adverse reactions associated with CR vaccination were observed in the handicapped patients. A nosocomial outbreak of influenza A H1N1 occurred in the ward with asthmatic children, but none of the 19 CR-trivalent vaccinees became infected. However, five of 20 non-vaccinees in the same ward, and ten of 30 vaccinees in another ward that received inactivated split vaccine became infected. The CR vaccines demonstrated significant protective effects against natural exposure to the A H1N1 virus, and were well tolerated and safe when given to patients with bronchial asthma and severe psychomotor retardation.
Url:
DOI: 10.1016/0264-410X(93)90361-Z
Affiliations:
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xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Shibata, Rumiko" sort="Shibata, Rumiko" uniqKey="Shibata R" first="Rumiko" last="Shibata">Rumiko Shibata</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>The National Minami Fukuoka Chest Hospital, 4-39-1, Yakatabaru, Minami-ku, Fukuoka 815</wicri:regionArea><wicri:noRegion>Fukuoka 815</wicri:noRegion></affiliation></author><author><name sortKey="Nishima, Sankei" sort="Nishima, Sankei" uniqKey="Nishima S" first="Sankei" last="Nishima">Sankei Nishima</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>The National Minami Fukuoka Chest Hospital, 4-39-1, Yakatabaru, Minami-ku, Fukuoka 815</wicri:regionArea><wicri:noRegion>Fukuoka 815</wicri:noRegion></affiliation></author><author><name sortKey="Yamane, Nobuhisa" sort="Yamane, Nobuhisa" uniqKey="Yamane N" first="Nobuhisa" last="Yamane">Nobuhisa Yamane</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Laboratory Medicine, Kumamoto University Medical School, 1-1-1, Honjo, Kumamoto 860</wicri:regionArea><wicri:noRegion>Kumamoto 860</wicri:noRegion></affiliation></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="853">853</biblScope><biblScope unit="page" to="858">858</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenovirus type</term><term>Adverse reactions</term><term>Antibody responses</term><term>Antibody titres</term><term>Asthma</term><term>Asthmatic</term><term>Asthmatic children</term><term>Attenuated</term><term>Attenuated influenza vaccine</term><term>Bivalent</term><term>Body temperature</term><term>Bronchial asthma</term><term>Exact test</term><term>Febrile</term><term>Immunization</term><term>Influenza</term><term>Influenza virus vaccines</term><term>Inoculated</term><term>Inoculation</term><term>Monovalent</term><term>Monovalent vaccine</term><term>Nosocomial</term><term>Nosocomial outbreak</term><term>Outbreak</term><term>Reassortant</term><term>Research institute</term><term>Seronegative</term><term>Seronegative children</term><term>Seropositive</term><term>Severe psychomotor retardation</term><term>Split vaccine</term><term>Titre</term><term>Trivalent</term><term>Trivalent vaccine</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine preparations</term><term>Vaccine strain</term><term>Vaccine strains</term><term>Vaccinee</term><term>Virus isolation</term><term>Young children</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Live attenuated cold-adapted reassortant (CR) influenza virus vaccines were evaluated in institutionalized asthmatic children and severe psychomotor-retarded (SPR) patients. Almost all the vaccines were seropositive to the vaccine strains before immunization. Trivalent CR vaccine (containing A H1N1 (CR-125), A H3N2 (CR-149) and B (CRB-117)), bivalent CR vaccine (CR-125 and CR-149) and monovalent CRB-117 were inoculated to 19 asthmatic children and 36 and 16 SPR patients, respectively. Overall 49, 22, 11% of vaccinees were infected by A H1N1, A H3N2 or B vaccine viruses, respectively, as indicated by significant haemagglutination-inhibition (HI) antibody titre rises 4 weeks after inoculation. No severe adverse reactions associated with CR vaccination were observed in the handicapped patients. A nosocomial outbreak of influenza A H1N1 occurred in the ward with asthmatic children, but none of the 19 CR-trivalent vaccinees became infected. However, five of 20 non-vaccinees in the same ward, and ten of 30 vaccinees in another ward that received inactivated split vaccine became infected. The CR vaccines demonstrated significant protective effects against natural exposure to the A H1N1 virus, and were well tolerated and safe when given to patients with bronchial asthma and severe psychomotor retardation.</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Kyūshū</li><li>Michigan</li><li>Préfecture de Fukuoka</li></region><settlement><li>Fukuoka</li></settlement><orgName><li>Université de Kyūshū</li></orgName></list><tree><country name="Japon"><region name="Kyūshū"><name sortKey="Miyazaki, Chiaki" sort="Miyazaki, Chiaki" uniqKey="Miyazaki C" first="Chiaki" last="Miyazaki">Chiaki Miyazaki</name></region><name sortKey="Kusuhara, Koichi" sort="Kusuhara, Koichi" uniqKey="Kusuhara K" first="Koichi" last="Kusuhara">Koichi Kusuhara</name><name sortKey="Nakayama, Minako" sort="Nakayama, Minako" uniqKey="Nakayama M" first="Minako" last="Nakayama">Minako Nakayama</name><name sortKey="Nishima, Sankei" sort="Nishima, Sankei" uniqKey="Nishima S" first="Sankei" last="Nishima">Sankei Nishima</name><name sortKey="Okada, Kenji" sort="Okada, Kenji" uniqKey="Okada K" first="Kenji" last="Okada">Kenji Okada</name><name sortKey="Shibata, Rumiko" sort="Shibata, Rumiko" uniqKey="Shibata R" first="Rumiko" last="Shibata">Rumiko Shibata</name><name sortKey="Tanaka, Yoshifumi" sort="Tanaka, Yoshifumi" uniqKey="Tanaka Y" first="Yoshifumi" last="Tanaka">Yoshifumi Tanaka</name><name sortKey="Tokugawa, Ken" sort="Tokugawa, Ken" uniqKey="Tokugawa K" first="Ken" last="Tokugawa">Ken Tokugawa</name><name sortKey="Ueda, Kohji" sort="Ueda, Kohji" uniqKey="Ueda K" first="Kohji" last="Ueda">Kohji Ueda</name><name sortKey="Yamane, Nobuhisa" sort="Yamane, Nobuhisa" uniqKey="Yamane N" first="Nobuhisa" last="Yamane">Nobuhisa Yamane</name></country><country name="États-Unis"><region name="Michigan"><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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